ARHGAP35

Across TCGA patient cohorts, ARHGAP35 mutation is significantly associated with the RNA expression of many other genes, with 3,235 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ARHGAP35-associated genes across cancer lineages are ITGAE, MIR3125, and MRPS11. Each is linked with ARHGAP35 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP35-to-partner and partner-to-ARHGAP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAE grouped by ARHGAP35-low versus ARHGAP35-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP35→partner) and Y-score (partner→ARHGAP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ITGAE →	+0.378	+3.026	.003	<.001	3	4
BLCA	MIR3125 →	+0.877	+2.144	<.001	.003	3	4
UCEC	MRPS11 →	+0.181	+0.955	.006	.001	3	3
UCEC	NOP10 →	+0.214	+1.265	.004	.005	3	3
UCEC	PTP4A3 →	-0.451	-1.677	<.001	<.001	3	3
COAD	CDCA2 →	+0.877	+3.013	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,235 associations by consensus.

ITGAE by ARHGAP35 expression — COAD

Explore this box plot interactively →