ARHGAP35

Across TCGA cell cohorts, ARHGAP35 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,771 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ARHGAP35-associated GO terms across cancer lineages are Establishment or maintenance of actin cytoskeleton polarity, Negative regulation of calcium ion export across plasma membrane, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with ARHGAP35 in more than 15 cancer types. Because this analysis shows association rather than direction, both ARHGAP35-to-partner and partner-to-ARHGAP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment or maintenance of actin cytoskeleton polarity grouped by ARHGAP35-low versus ARHGAP35-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP35→partner) and Y-score (partner→ARHGAP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Establishment or maintenance of actin cytoskeleton polarity →	+0.298	+1.050	<.001	<.001	3	16
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.095	+1.132	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.216	+1.068	<.001	<.001	3	16
STOMACH	Endosomal transport →	+0.061	+1.118	.002	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.058	+0.945	<.001	<.001	3	16
BONE	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.129	+0.986	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,771 associations by consensus.

Establishment or maintenance of actin cytoskeleton polarity by ARHGAP35 expression — CNS

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