ARHGAP35

Across TCGA cell cohorts, ARHGAP35 mutation is significantly associated with the RNA expression of many other genes, with 730 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGAP35-associated genes across cancer lineages are CTC1, BHLHE23, and RIC8B. Each is linked with ARHGAP35 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP35-to-partner and partner-to-ARHGAP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTC1 grouped by ARHGAP35-low versus ARHGAP35-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP35→partner) and Y-score (partner→ARHGAP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTC1 →	+1.204	+3.260	<.001	.005	3	3
CNS	BHLHE23 →	+0.014	+4.754	<.001	.005	3	2
LARGE_INTESTINE	RIC8B →	+0.557	+3.364	.001	.002	3	2
LARGE_INTESTINE	MAPT →	+1.151	+3.169	<.001	.009	2	3
SKIN	C5orf52 →	+0.030	+4.415	<.001	.007	3	2
BLOOD_Leukemia	ZBED4 →	+0.654	+3.199	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 730 associations by consensus.

CTC1 by ARHGAP35 expression — BLOOD_Leukemia

Explore this box plot interactively →