ARHGAP33

Across TCGA patient cohorts, ARHGAP33 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP33-associated genes across cancer lineages are mTOR_pS2448, ATM, and eIF4E. Each is linked with ARHGAP33 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP33-to-partner and partner-to-ARHGAP33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ARHGAP33-low versus ARHGAP33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP33→partner) and Y-score (partner→ARHGAP33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.132	-1.565	.006	.017	3	3
UCEC	ATM →	-0.383	-1.222	.009	.035	3	3
STAD	eIF4E →	+0.199	+3.000	.034	.036	3	2
STAD	p90 RSK →	+0.280	+3.000	.032	.036	3	2
STAD	PCNA →	+0.412	+3.000	.005	.036	2	3
STAD	Caspase-7-cleavedD198 →	+1.044	+3.000	.006	.036	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

mTOR_pS2448 by ARHGAP33 expression — UCEC

Explore this box plot interactively →