ARHGAP33

Across TCGA cell cohorts, ARHGAP33 mutation is significantly associated with the RNA expression of many other genes, with 1,130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP33-associated genes across cancer lineages are DEFB134, PNLIPRP1, and SEPTIN3. Each is linked with ARHGAP33 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP33-to-partner and partner-to-ARHGAP33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB134 grouped by ARHGAP33-low versus ARHGAP33-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP33→partner) and Y-score (partner→ARHGAP33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DEFB134 →	+0.131	+4.882	<.001	.001	3	2
PANCREAS	PNLIPRP1 →	+0.049	+5.000	<.001	.006	3	2
LARGE_INTESTINE	SEPTIN3 →	+0.924	+2.459	.007	.006	3	2
LARGE_INTESTINE	HSCB →	+0.529	+3.584	.001	<.001	3	2
LARGE_INTESTINE	CCP110 →	+0.658	+3.321	.001	.003	3	2
LARGE_INTESTINE	RIC8B →	+0.440	+2.850	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,130 associations by consensus.

DEFB134 by ARHGAP33 expression — SOFT_TISSUE

Explore this box plot interactively →