ARHGAP32

Across TCGA patient cohorts, ARHGAP32 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP32-associated genes across cancer lineages are ASNS, YAP_pS127, and GAPDH. Each is linked with ARHGAP32 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGAP32-to-partner and partner-to-ARHGAP32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ARHGAP32-low versus ARHGAP32-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP32→partner) and Y-score (partner→ARHGAP32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.371	+1.815	.011	.016	3	5
SKCM	YAP_pS127 →	-0.373	-2.321	.013	.033	3	4
UCEC	GAPDH →	+0.312	+1.440	.022	.020	3	3
COAD	PDCD4 →	-0.375	-2.991	.016	<.001	3	3
SKCM	Cyclin-B1 →	+0.519	+2.597	.002	.005	3	3
LUAD	PKC-b-II_pS660 →	-0.498	-2.321	.008	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

ASNS by ARHGAP32 expression — COAD

Explore this box plot interactively →