ARHGAP32

Across TCGA cell cohorts, ARHGAP32 mutation is significantly associated with the RNA expression of many other genes, with 1,359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP32-associated genes across cancer lineages are PYY, LGI3, and SOX1. Each is linked with ARHGAP32 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP32-to-partner and partner-to-ARHGAP32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYY grouped by ARHGAP32-low versus ARHGAP32-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP32→partner) and Y-score (partner→ARHGAP32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PYY →	+0.104	+3.612	.008	.004	3	2
LARGE_INTESTINE	LGI3 →	+0.436	+2.906	<.001	<.001	3	2
BLOOD_Leukemia	SOX1 →	+0.453	+3.564	<.001	.003	3	2
BLOOD_Leukemia	NTF4 →	+0.161	+4.108	<.001	<.001	3	2
BLOOD_Leukemia	TRIL →	+0.124	+3.180	<.001	.004	3	2
LARGE_INTESTINE	CCDC134 →	+0.752	+2.502	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,359 associations by consensus.

PYY by ARHGAP32 expression — BLOOD_Leukemia

Explore this box plot interactively →