ARHGAP31

Across TCGA patient cohorts, ARHGAP31 mutation is significantly associated with the RNA expression of many other genes, with 4,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP31-associated genes across cancer lineages are BLOC1S2, BUB3, and CHAF1A. Each is linked with ARHGAP31 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP31-to-partner and partner-to-ARHGAP31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BLOC1S2 grouped by ARHGAP31-low versus ARHGAP31-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP31→partner) and Y-score (partner→ARHGAP31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BLOC1S2 →	+0.463	+3.710	.001	<.001	3	4
STAD	BUB3 →	+0.593	+3.492	<.001	.002	3	4
UCEC	CHAF1A →	+0.624	+2.230	<.001	<.001	3	4
COAD	ZNF695 →	+0.509	+3.710	<.001	<.001	3	4
UCEC	CDKN3 →	+0.659	+1.638	<.001	<.001	3	4
COAD	GOT1 →	+0.433	+3.598	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,900 associations by consensus.

BLOC1S2 by ARHGAP31 expression — COAD

Explore this box plot interactively →