ARHGAP31

Across TCGA cell cohorts, ARHGAP31 mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP31-associated genes across cancer lineages are WFDC8, DDI1, and WFDC10A. Each is linked with ARHGAP31 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP31-to-partner and partner-to-ARHGAP31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC8 grouped by ARHGAP31-low versus ARHGAP31-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP31→partner) and Y-score (partner→ARHGAP31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	WFDC8 →	+0.052	+4.044	<.001	.001	3	2
URINARY_TRACT	DDI1 →	+0.005	+3.584	<.001	.005	3	2
URINARY_TRACT	WFDC10A →	+0.038	+4.044	<.001	.001	3	2
URINARY_TRACT	C3orf22 →	+0.013	+3.584	<.001	.005	3	2
BLOOD_Myeloma	TCF21 →	+0.005	+3.285	<.001	.009	3	2
LUNG_NSCLC_LUAD	STRA8 →	+0.320	+3.374	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

WFDC8 by ARHGAP31 expression — URINARY_TRACT

Explore this box plot interactively →