ARHGAP28

Across TCGA pan-cancer cohorts, ARHGAP28 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ARHGAP28 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ARHGAP28 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ARHGAP28 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, ESCA, and DLBC are the cancer types where ARHGAP28 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.656	.008	30	view →
ESCA	OS	Median	II,III,IV	0.246	0.559	.001	15	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
BRCA	OS	Median	IV	0.106	0.791	<.001	12	view →
LUAD	OS	Median	III,IV	0.163	0.663	.012	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	DFS	Median	II,III,IV	0.882	0.324	.026	6	view →
SKCM	DFS	Median	III,IV	0.164	0.660	.004	5	view →
STAD	DFS	Median	III,IV	0.846	0.334	.040	3	view →
LUSC	DFS	Median	All	1.000	0.653	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ARHGAP28–UCEC (OS)

Open the UCEC breakdown →