ARHGAP28

Across TCGA patient cohorts, ARHGAP28 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP28-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and Cyclin-E1. Each is linked with ARHGAP28 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP28-to-partner and partner-to-ARHGAP28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARHGAP28-low versus ARHGAP28-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP28→partner) and Y-score (partner→ARHGAP28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.304	+3.016	<.001	.018	3	3
UCEC	Cyclin-B1 →	+0.774	+3.807	<.001	<.001	3	3
COAD	Cyclin-E1 →	+0.290	+2.330	.010	.020	3	3
SKCM	4E-BP1 →	+0.267	+2.584	.037	.010	3	3
UCEC	EGFR_pY1068 →	-0.359	-3.459	<.001	<.001	3	2
UCEC	FoxM1 →	+0.248	+2.321	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by ARHGAP28 expression — COAD

Explore this box plot interactively →