ARHGAP25

Across TCGA pan-cancer cohorts, ARHGAP25 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ARHGAP25 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ARHGAP25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGAP25 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, LUAD, and PDAC are the cancer types where ARHGAP25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.859	1.000	.028	54	view →
LUAD	DFS	Median	All	0.792	0.480	<.001	22	view →
PDAC	OS	Median	III,IV	0.326	0.829	.004	10	view →
HNSC	DFS	Median	II,III,IV	0.897	0.993	.005	8	view →
UCEC	DFS	Median	II,III,IV	0.826	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ARHGAP25–COAD (DFS)

Open the COAD breakdown →