ARHGAP24

Across TCGA pan-cancer cohorts, ARHGAP24 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ARHGAP24’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ARHGAP24 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ARHGAP24 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where ARHGAP24 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGAP24 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.842	<.001	12	view →
LUAD	Female	III,IV	−0.893	<.001	9	view →
LSCC	Male	II,III,IV	−0.810	<.001	8	view →
PDAC	Male	II,III,IV	−0.664	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ARHGAP24–CCRCC

Open the CCRCC breakdown →