ARHGAP23

Across TCGA patient cohorts, ARHGAP23 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP23-associated genes across cancer lineages are Fibronectin, MEK1, and eEF2. Each is linked with ARHGAP23 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP23-to-partner and partner-to-ARHGAP23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by ARHGAP23-low versus ARHGAP23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP23→partner) and Y-score (partner→ARHGAP23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.267	-1.765	.031	.014	3	2
UCEC	MEK1 →	+0.442	+3.000	.001	<.001	3	2
UCEC	eEF2 →	+0.329	+1.415	.014	.046	3	1
UCEC	EGFR_pY1068 →	-0.319	-2.169	<.001	.003	3	1
UCEC	eIF4E →	+0.218	+2.700	.005	.006	3	1
UCEC	A-Raf_pS299 →	-0.160	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Fibronectin by ARHGAP23 expression — UCEC

Explore this box plot interactively →