ARHGAP22

Across TCGA patient cohorts, ARHGAP22 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP22-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and PCNA. Each is linked with ARHGAP22 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP22-to-partner and partner-to-ARHGAP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ARHGAP22-low versus ARHGAP22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP22→partner) and Y-score (partner→ARHGAP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.158	+2.321	.007	.005	3	3
COAD	JNK_pT183_Y185 →	-0.241	-3.000	.033	.035	3	2
UCEC	PCNA →	+0.250	+2.247	<.001	.001	3	2
UCEC	PDCD4 →	-0.382	-1.807	.007	.024	3	2
UCEC	Caspase-8 →	-0.182	-2.295	.018	<.001	3	2
UCEC	Di-Ras3 →	-0.143	-2.893	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ERK2 by ARHGAP22 expression — UCEC

Explore this box plot interactively →