ARHGAP22

Across TCGA cell cohorts, ARHGAP22 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,663 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ARHGAP22-associated GO terms across cancer lineages are Regulation of cell-substrate junction organization, Positive regulation of cell-substrate junction organization, and Peptidyl-lysine oxidation. Each is linked with ARHGAP22 in more than 12 cancer types. Because this analysis shows association rather than direction, both ARHGAP22-to-partner and partner-to-ARHGAP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction organization grouped by ARHGAP22-low versus ARHGAP22-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP22→partner) and Y-score (partner→ARHGAP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction organization →	+0.154	+2.289	<.001	<.001	3	13
BONE	Positive regulation of cell-substrate junction organization →	+0.160	+2.277	<.001	<.001	3	13
URINARY_TRACT	Peptidyl-lysine oxidation →	+1.644	+2.516	<.001	<.001	3	12
LIVER	Regulation of establishment of T cell polarity →	+0.257	+2.330	.001	.005	3	12
URINARY_TRACT	Actin filament depolymerization →	+0.232	+2.938	<.001	<.001	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.214	+2.267	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,663 associations by consensus.

Regulation of cell-substrate junction organization by ARHGAP22 expression — BONE

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