ARHGAP22

Across TCGA cell cohorts, ARHGAP22 mutation is significantly associated with the RNA expression of many other genes, with 852 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP22-associated genes across cancer lineages are DCK, METAP1, and H2AZ1. Each is linked with ARHGAP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP22-to-partner and partner-to-ARHGAP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCK grouped by ARHGAP22-low versus ARHGAP22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP22→partner) and Y-score (partner→ARHGAP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCK →	+0.599	+2.743	<.001	.001	3	2
LARGE_INTESTINE	METAP1 →	+0.491	+2.743	.005	.001	3	2
LARGE_INTESTINE	H2AZ1 →	+0.711	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	PSIP1 →	+0.739	+2.743	.001	.001	3	2
LARGE_INTESTINE	MRPL1 →	+0.529	+3.321	.005	.003	3	2
LARGE_INTESTINE	CD300H →	+0.014	+2.415	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 852 associations by consensus.

DCK by ARHGAP22 expression — LARGE_INTESTINE

Explore this box plot interactively →