ARHGAP22-IT1

Across TCGA pan-cancer cohorts, ARHGAP22-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated ARHGAP22-IT1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ARHGAP22-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGAP22-IT1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and LGG show a favorable association.

ACC, BLCA, and KICH are the cancer types where ARHGAP22-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.010	0.667	<.001	135	view →
BLCA	OS	Tertile	III,IV	0.393	0.700	<.001	135	view →
KICH	OS	Tertile	All	0.742	0.975	<.001	99	view →
COAD	OS	Tertile	All	0.465	0.819	<.001	72	view →
THYM	OS	Tertile	All	0.332	0.893	<.001	57	view →
UCEC	DFS	Tertile	All	0.361	0.671	<.001	42	view →
CHOL	DFS	Tertile	All	0.861	0.296	.012	24	view →
LGG	OS	Tertile	All	0.970	0.794	.005	21	view →
THCA	OS	Quartile	All	0.954	0.987	.015	15	view →
HNSC	OS	Tertile	All	0.119	0.407	.027	15	view →
OV	OS	Tertile	IV	0.463	0.785	.010	12	view →
LIHC	OS	Tertile	II,III,IV	1.000	0.418	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

ARHGAP22-IT1–ACC (DFS)

Open the ACC breakdown →