ARHGAP20

Across TCGA patient cohorts, ARHGAP20 mutation is significantly associated with the RNA expression of many other genes, with 3,939 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP20-associated genes across cancer lineages are PKN3, TEDC2, and RBM47. Each is linked with ARHGAP20 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP20-to-partner and partner-to-ARHGAP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by ARHGAP20-low versus ARHGAP20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP20→partner) and Y-score (partner→ARHGAP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+0.662	+1.513	<.001	<.001	3	3
UCEC	TEDC2 →	+0.424	+2.247	.001	.001	3	3
UCEC	RBM47 →	+0.385	+2.060	.007	<.001	3	3
UCEC	PDZD8 →	+0.552	+1.513	.001	<.001	3	3
UCEC	FBXO22 →	+0.463	+2.071	<.001	<.001	3	3
UCEC	ORAI3 →	-0.356	-2.226	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,939 associations by consensus.

PKN3 by ARHGAP20 expression — UCEC

Explore this box plot interactively →