ARHGAP20

Across TCGA patient cohorts, ARHGAP20 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP20-associated genes across cancer lineages are Shc_pY317, ATM, and 14-3-3_beta. Each is linked with ARHGAP20 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP20-to-partner and partner-to-ARHGAP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ARHGAP20-low versus ARHGAP20-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP20→partner) and Y-score (partner→ARHGAP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Shc_pY317 →	-0.209	-2.576	.002	.011	3	3
UCEC	ATM →	-0.535	-1.536	<.001	.002	3	3
COAD	14-3-3_beta →	-0.195	-3.674	.023	.001	3	2
COAD	eEF2 →	+0.260	+1.882	.036	.031	3	2
COAD	A-Raf_pS299 →	-0.194	-2.576	.006	.011	2	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.344	+0.999	.018	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Shc_pY317 by ARHGAP20 expression — COAD

Explore this box plot interactively →