ARHGAP19-SLIT1

Across TCGA pan-cancer cohorts, ARHGAP19-SLIT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated ARHGAP19-SLIT1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ARHGAP19-SLIT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGAP19-SLIT1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LGG show a favorable association.

UVM, ACC, and ESCA are the cancer types where ARHGAP19-SLIT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.433	0.846	<.001	137	view →
ACC	DFS	Tertile	All	0.315	0.673	<.001	83	view →
ESCA	OS	Tertile	All	0.496	0.783	<.001	81	view →
UCEC	DFS	Median	All	0.791	0.874	.003	70	view →
PAAD	DFS	Tertile	All	0.558	0.261	<.001	49	view →
MESO	OS	Median	III,IV	0.291	0.472	.016	43	view →
LGG	OS	Median	All	0.541	0.373	<.001	28	view →
HNSC	DFS	Tertile	III,IV	0.427	0.649	.029	24	view →
TGCT	DFS	Tertile	All	0.468	0.823	<.001	20	view →
LUSC	DFS	Tertile	All	0.267	0.450	.003	16	view →
THYM	OS	Tertile	II,III,IV	1.000	0.663	.005	13	view →
SKCM	OS	Quartile	III,IV	0.905	0.759	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

ARHGAP19-SLIT1–UVM (DFS)

Open the UVM breakdown →