ARHGAP17

Across TCGA patient cohorts, ARHGAP17 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP17-associated genes across cancer lineages are Cyclin-B1, FoxM1, and ERK2. Each is linked with ARHGAP17 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP17-to-partner and partner-to-ARHGAP17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ARHGAP17-low versus ARHGAP17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP17→partner) and Y-score (partner→ARHGAP17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.612	+1.830	<.001	<.001	3	3
LUSC	FoxM1 →	+0.304	+2.179	.023	.035	2	3
UCEC	ERK2 →	+0.133	+1.273	.013	.007	3	2
UCEC	ACC1 →	+0.332	+1.428	.001	.025	3	2
UCEC	Rad50 →	-0.175	-1.632	.010	<.001	3	2
UCEC	STAT3_pY705 →	-0.301	-1.174	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Cyclin-B1 by ARHGAP17 expression — UCEC

Explore this box plot interactively →