ARHGAP15

Across TCGA patient cohorts, ARHGAP15 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP15-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_epsilon, and Notch1. Each is linked with ARHGAP15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP15-to-partner and partner-to-ARHGAP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ARHGAP15-low versus ARHGAP15-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP15→partner) and Y-score (partner→ARHGAP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p62 Lck ligand →	+0.440	+2.321	.022	.035	3	3
SKCM	14-3-3_epsilon →	+0.138	+3.169	.022	.018	3	3
UCEC	Notch1 →	+0.251	+2.598	<.001	.005	3	3
UCEC	p27 →	-0.198	-3.169	.028	.018	3	3
COAD	ERK2 →	+0.241	+3.347	.008	.005	3	2
UCEC	Rab25 →	-0.278	-2.321	.042	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

p62 Lck ligand by ARHGAP15 expression — SKCM

Explore this box plot interactively →