ARHGAP15

Across TCGA cell cohorts, ARHGAP15 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP15-associated genes across cancer lineages are PSG11, ZNF831, and MAGEB1. Each is linked with ARHGAP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP15-to-partner and partner-to-ARHGAP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSG11 grouped by ARHGAP15-low versus ARHGAP15-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP15→partner) and Y-score (partner→ARHGAP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSG11 →	+0.134	+3.070	<.001	.009	3	2
CNS	ZNF831 →	+0.070	+3.832	<.001	.005	3	2
LARGE_INTESTINE	MAGEB1 →	+0.159	+2.878	.002	.009	3	2
SKIN	MAGEB4 →	+0.010	+5.022	<.001	.002	3	2
OESOPHAGUS	GPR31 →	+0.016	+4.906	<.001	.006	3	1
OESOPHAGUS	SPHKAP →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PSG11 by ARHGAP15 expression — LUNG_SCLC

Explore this box plot interactively →