ARHGAP12

Across TCGA patient cohorts, ARHGAP12 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP12-associated genes across cancer lineages are PDCD4, mTOR_pS2448, and p62 Lck ligand. Each is linked with ARHGAP12 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP12-to-partner and partner-to-ARHGAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ARHGAP12-low versus ARHGAP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP12→partner) and Y-score (partner→ARHGAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.337	-1.115	.013	.026	3	4
UCEC	mTOR_pS2448 →	-0.105	-1.752	.015	.011	3	2
UCEC	p62 Lck ligand →	+0.367	+2.415	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.073	-1.584	.037	.032	3	2
UCEC	ATM →	-0.503	-2.156	<.001	.002	3	2
UCEC	4E-BP1_pT37_T46 →	-0.216	-1.893	.048	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDCD4 by ARHGAP12 expression — UCEC

Explore this box plot interactively →