ARHGAP12

Across TCGA cell cohorts, ARHGAP12 mutation is significantly associated with the RNA expression of many other genes, with 440 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP12-associated genes across cancer lineages are CBY1, JOSD1, and TIMM9. Each is linked with ARHGAP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP12-to-partner and partner-to-ARHGAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by ARHGAP12-low versus ARHGAP12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP12→partner) and Y-score (partner→ARHGAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.745	+3.330	<.001	.002	3	1
LARGE_INTESTINE	JOSD1 →	+0.564	+3.364	.003	.002	3	1
LARGE_INTESTINE	TIMM9 →	+0.582	+3.364	<.001	.002	3	1
LARGE_INTESTINE	VAPA →	+0.661	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CLUAP1 →	+0.733	+3.252	<.001	.002	3	1
LARGE_INTESTINE	ASPN →	+0.029	+3.011	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 440 associations by consensus.

CBY1 by ARHGAP12 expression — LARGE_INTESTINE

Explore this box plot interactively →