ARHGAP10

Across TCGA pan-cancer cohorts, ARHGAP10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ARHGAP10 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ARHGAP10 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGAP10 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where ARHGAP10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.849	0.336	<.001	65	view →
HNSC	OS	Tertile	II,III,IV	0.949	0.775	.013	21	view →
GBM	OS	Quartile	All	0.729	0.973	.008	8	view →
LSCC	OS	Median	All	0.793	1.000	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ARHGAP10–CCRCC (DFS)

Open the CCRCC breakdown →