ARHGAP10

Across TCGA patient cohorts, ARHGAP10 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP10-associated genes across cancer lineages are EGFR_pY1068, MSH2, and ATM. Each is linked with ARHGAP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP10-to-partner and partner-to-ARHGAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ARHGAP10-low versus ARHGAP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP10→partner) and Y-score (partner→ARHGAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.204	-1.847	.009	.007	3	2
UCEC	MSH2 →	-0.243	-2.143	<.001	.002	3	2
UCEC	ATM →	-0.497	-2.584	<.001	.001	3	2
SKCM	Fibronectin →	+0.460	+2.000	.022	.031	3	1
SKCM	FoxM1 →	-0.195	-3.000	.034	.034	3	1
SKCM	FOXO3a →	-0.113	-2.321	.029	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR_pY1068 by ARHGAP10 expression — UCEC

Explore this box plot interactively →