ARHGAP10

Across TCGA cell cohorts, ARHGAP10 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP10-associated genes across cancer lineages are AVP, LRRC74A, and CABP5. Each is linked with ARHGAP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP10-to-partner and partner-to-ARHGAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by ARHGAP10-low versus ARHGAP10-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP10→partner) and Y-score (partner→ARHGAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
LUNG_SCLC	LRRC74A →	+0.129	+4.269	<.001	.005	3	1
BLOOD_Lymphoma	CABP5 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DEFB129 →	+0.043	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	REG3G →	+0.040	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CABS1 →	+0.073	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

AVP by ARHGAP10 expression — BLOOD_Lymphoma

Explore this box plot interactively →