ARHGAP10

Across TCGA cell cohorts, ARHGAP10 mutation is significantly associated with the mutation status of many other genes, with 4,382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP10-associated genes across cancer lineages are TLR5, NUP133, and PARD3B. Each is linked with ARHGAP10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP10-to-partner and partner-to-ARHGAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLR5 grouped by ARHGAP10-low versus ARHGAP10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP10→partner) and Y-score (partner→ARHGAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TLR5 →	+4.187	+5.000	.008	.008	1	4
SKIN	NUP133 →	+4.824	+5.392	.004	.004	1	4
LARGE_INTESTINE	PARD3B →	+2.182	+2.273	.002	.002	1	4
BLOOD_Lymphoma	MATR3 →	+5.014	+5.584	.003	.003	1	3
LUNG_NSCLC_LUAD	POLD1 →	+5.772	+5.772	.002	.002	1	3
BLOOD_Leukemia	LHX3 →	+4.894	+4.894	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

TLR5 by ARHGAP10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →