ARHGAP1

Across TCGA patient cohorts, ARHGAP1 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP1-associated genes across cancer lineages are RN7SL392P, TOMM22P5, and MIR4450. Each is linked with ARHGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP1-to-partner and partner-to-ARHGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL392P grouped by ARHGAP1-low versus ARHGAP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP1→partner) and Y-score (partner→ARHGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL392P →	+0.076	+4.147	<.001	.008	3	2
UCEC	TOMM22P5 →	+0.441	+2.839	<.001	.009	3	2
SKCM	MIR4450 →	+0.470	+4.181	<.001	<.001	3	2
UCEC	RN7SL126P →	+0.224	+2.818	.009	.005	3	1
SKCM	LINC01815 →	+0.057	+4.897	<.001	.002	3	1
SKCM	COX6B1P2 →	+0.176	+3.877	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

RN7SL392P by ARHGAP1 expression — SKCM

Explore this box plot interactively →