ARHGAP1

Across TCGA patient cohorts, ARHGAP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP1-associated genes across cancer lineages are 14-3-3_beta, JNK2, and N-Ras. Each is linked with ARHGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP1-to-partner and partner-to-ARHGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ARHGAP1-low versus ARHGAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP1→partner) and Y-score (partner→ARHGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.142	-2.986	.014	.037	2	2
UCEC	JNK2 →	+0.262	+2.817	.022	.036	3	1
UCEC	N-Ras →	-0.150	-2.986	.029	.037	2	1
UCEC	Rab25 →	-0.519	-3.000	.006	.037	2	1
UCEC	c-Jun_pS73 →	-0.200	-3.000	.029	.037	2	1
UCEC	C-Raf →	+0.186	+3.000	.025	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_beta by ARHGAP1 expression — UCEC

Explore this box plot interactively →