ARHGAP1

Across TCGA cell cohorts, ARHGAP1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP1-associated genes across cancer lineages are SSX7, LILRA1, and BPIFA1. Each is linked with ARHGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP1-to-partner and partner-to-ARHGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX7 grouped by ARHGAP1-low versus ARHGAP1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP1→partner) and Y-score (partner→ARHGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
LARGE_INTESTINE	LILRA1 →	+0.013	+4.095	.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.178	+4.273	<.001	.006	3	1
BLOOD_Leukemia	UBQLN3 →	+0.029	+4.551	<.001	.004	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SSX7 by ARHGAP1 expression — STOMACH

Explore this box plot interactively →