Across TCGA patient cohorts, ARGFX mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ARGFX-associated genes across cancer lineages are Paxillin, PI3K-p85, and PRAS40_pT246. Each is linked with ARGFX in more than 1 cancer types. Because this analysis shows association rather than direction, both ARGFX-to-partner and partner-to-ARGFX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARGFX→partner) and Y-score (partner→ARGFX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Paxillin →	+0.510	+2.700	.005	.006	3	1
SKCM	PI3K-p85 →	+0.200	+2.000	.034	.031	3	1
SKCM	PRAS40_pT246 →	+0.185	+3.182	.009	.009	3	1
SKCM	Src →	-0.213	-2.700	.038	.006	3	1
SKCM	YB-1_pS102 →	+0.216	+2.186	.004	.032	3	1
SKCM	CD31 →	-0.215	-3.000	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

ARGFX survival (RNA) · tumor vs normal (RNA) · all ARGFX data types