ARG2

Across TCGA cell cohorts, ARG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,324 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARG2-associated GO terms across cancer lineages are Negative regulation of macrophage inflammatory protein 1 alpha production, Regulation of activated CD8-positive, alpha-beta T cell apoptotic process, and Regulation of macrophage inflammatory protein 1 alpha production. Each is linked with ARG2 in more than 15 cancer types. Because this analysis shows association rather than direction, both ARG2-to-partner and partner-to-ARG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage inflammatory protein 1 alpha production grouped by ARG2-low versus ARG2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARG2→partner) and Y-score (partner→ARG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of macrophage inflammatory protein 1 alpha production →	+1.444	+2.087	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of activated CD8-positive, alpha-beta T cell apoptotic process →	+1.038	+1.432	<.001	<.001	3	15
BLOOD_Myeloma	Regulation of macrophage inflammatory protein 1 alpha production →	+1.655	+2.091	<.001	<.001	3	15
BREAST	Negative regulation of defense response to bacterium →	+0.715	+1.172	<.001	<.001	3	12
LARGE_INTESTINE	Negative regulation of chemokine (C-C motif) ligand 5 production →	+0.279	+1.262	.001	<.001	3	12
BONE	Urea metabolic process →	+0.130	+1.670	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,324 associations by consensus.

Negative regulation of macrophage inflammatory protein 1 alpha production by ARG2 expression — BLOOD_Myeloma

Explore this box plot interactively →