ARFIP2

Across TCGA patient cohorts, ARFIP2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFIP2-associated genes across cancer lineages are Notch1, p27_pT198, and p38-MAPK_pT180_Y182. Each is linked with ARFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFIP2-to-partner and partner-to-ARFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ARFIP2-low versus ARFIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFIP2→partner) and Y-score (partner→ARFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.255	+4.000	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.117	+2.459	.009	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.574	-2.209	.002	.011	3	2
UCEC	EGFR_pY1068 →	-0.269	-2.906	.011	.001	3	1
UCEC	EGFR_pY1173 →	+0.111	+3.169	.001	.018	3	1
UCEC	eIF4G →	+0.309	+2.321	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Notch1 by ARFIP2 expression — UCEC

Explore this box plot interactively →