ARFIP1

Across TCGA pan-cancer cohorts, ARFIP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ARFIP1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ARFIP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARFIP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where ARFIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	51	view →
HNSC	DFS	Quartile	II,III,IV	0.988	0.834	.011	46	view →
LSCC	DFS	Median	All	0.382	1.000	<.001	44	view →
UCEC	DFS	Tertile	All	0.972	0.745	.004	26	view →
GBM	OS	Tertile	All	0.343	0.610	.002	20	view →
PDAC	DFS	Median	III,IV	0.979	0.463	.022	6	view →
LUAD	DFS	Quartile	All	0.853	0.995	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ARFIP1–CCRCC (DFS)

Open the CCRCC breakdown →