ARFGEF3

Across TCGA patient cohorts, ARFGEF3 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,217 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARFGEF3-associated proteins across cancer lineages are ARFGEF3_S1991, ARFGEF3_S2081, and PICK1. Each is linked with ARFGEF3 in more than 8 cancer types. Because this analysis shows association rather than direction, both ARFGEF3-to-partner and partner-to-ARFGEF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARFGEF3 versus ARFGEF3_S1991 in CCRCC, with a Pearson correlation of 0.80.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF3→partner) and Y-score (partner→ARFGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARFGEF3_S1991 →	+1.054	+1.316	<.001	<.001	3	9
LSCC	ARFGEF3_S2081 →	+0.927	+0.989	<.001	<.001	3	8
BRCA	PICK1 →	+0.447	+0.929	<.001	<.001	3	7
BRCA	DDAH1 →	+0.782	+1.764	<.001	<.001	3	7
BRCA	TTC39A →	+1.163	+1.870	<.001	<.001	3	6
GBM	MSN →	-0.580	-0.822	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,217 associations by consensus.

ARFGEF3 vs ARFGEF3_S1991 — CCRCC

Explore this scatter interactively →