ARFGEF3

Across TCGA patient cohorts, ARFGEF3 mutation is significantly associated with the RNA expression of many other genes, with 6,258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGEF3-associated genes across cancer lineages are WDR62, OIP5, and DUT. Each is linked with ARFGEF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARFGEF3-to-partner and partner-to-ARFGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR62 grouped by ARFGEF3-low versus ARFGEF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF3→partner) and Y-score (partner→ARFGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR62 →	+0.651	+2.046	<.001	<.001	3	5
UCEC	OIP5 →	+0.771	+2.057	<.001	<.001	3	5
UCEC	DUT →	+0.406	+1.759	<.001	.001	3	5
UCEC	HAUS8 →	+0.403	+2.222	<.001	<.001	3	5
UCEC	KIF23 →	+0.583	+2.828	<.001	<.001	3	5
UCEC	CHAF1A →	+0.741	+2.673	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,258 associations by consensus.

WDR62 by ARFGEF3 expression — UCEC

Explore this box plot interactively →