ARFGEF3

Across TCGA cell cohorts, ARFGEF3 mutation is significantly associated with the RNA expression of many other genes, with 1,201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARFGEF3-associated genes across cancer lineages are UFSP2, SPRR2B, and MIEF1. Each is linked with ARFGEF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARFGEF3-to-partner and partner-to-ARFGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UFSP2 grouped by ARFGEF3-low versus ARFGEF3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF3→partner) and Y-score (partner→ARFGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UFSP2 →	+0.570	+3.574	<.001	<.001	3	3
BLOOD_Lymphoma	SPRR2B →	+0.043	+4.058	<.001	.009	3	2
LARGE_INTESTINE	MIEF1 →	+0.541	+2.212	.002	<.001	3	2
LARGE_INTESTINE	TNRC6B →	+0.743	+2.479	<.001	<.001	3	2
LARGE_INTESTINE	HM13 →	-0.566	-2.619	<.001	<.001	3	2
LARGE_INTESTINE	C12orf57 →	+0.753	+2.782	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,201 associations by consensus.

UFSP2 by ARFGEF3 expression — BLOOD_Leukemia

Explore this box plot interactively →