ARFGEF2

Across TCGA patient cohorts, ARFGEF2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,534 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARFGEF2-associated genes across cancer lineages are ARHGEF25, TTC23, and RAB23. Each is linked with ARFGEF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ARFGEF2-to-partner and partner-to-ARFGEF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARFGEF2 versus ARHGEF25 in BRCA, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF2→partner) and Y-score (partner→ARFGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF25 →	-0.556	-0.239	.001	.007	3	7
BRCA	TTC23 →	-0.548	-0.311	.001	.002	3	6
COAD	RAB23 →	-0.710	-0.256	.001	<.001	3	6
HNSC	UACA →	-0.580	-0.201	.001	.001	3	6
OV	SMAD1 →	-0.555	-0.187	<.001	.002	3	5
CCRCC	PABPC4L →	-0.823	-0.211	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,534 associations by consensus.

ARFGEF2 vs ARHGEF25 — BRCA

Explore this scatter interactively →