ARFGEF2

Across TCGA patient cohorts, ARFGEF2 mutation is significantly associated with the RNA expression of many other genes, with 4,940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGEF2-associated genes across cancer lineages are SNRNP25, MCAT, and TRMU. Each is linked with ARFGEF2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARFGEF2-to-partner and partner-to-ARFGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRNP25 grouped by ARFGEF2-low versus ARFGEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF2→partner) and Y-score (partner→ARFGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRNP25 →	+0.571	+2.882	<.001	<.001	3	5
STAD	MCAT →	+0.564	+2.923	<.001	<.001	3	5
UCEC	TRMU →	+0.494	+2.115	<.001	<.001	3	5
STAD	TOMM40 →	+0.550	+2.239	.005	.005	2	6
COAD	BRIP1 →	+0.635	+3.459	<.001	.005	3	4
COAD	GINS4 →	+0.555	+3.196	.006	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,940 associations by consensus.

SNRNP25 by ARFGEF2 expression — UCEC

Explore this box plot interactively →