ARFGEF2

Across TCGA patient cohorts, ARFGEF2 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGEF2-associated genes across cancer lineages are Cyclin-B1, c-Kit, and Claudin-7. Each is linked with ARFGEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARFGEF2-to-partner and partner-to-ARFGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ARFGEF2-low versus ARFGEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF2→partner) and Y-score (partner→ARFGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.639	+2.137	<.001	<.001	3	4
STAD	c-Kit →	-0.390	-3.321	.008	.010	3	3
STAD	Claudin-7 →	+0.812	+3.321	.008	.010	3	3
UCEC	PCNA →	+0.160	+1.106	.008	.020	3	3
UCEC	TFRC →	+0.325	+1.247	.029	.041	3	3
COAD	Caspase-7-cleavedD198 →	+1.783	+3.008	<.001	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Cyclin-B1 by ARFGEF2 expression — UCEC

Explore this box plot interactively →