ARFGEF2

Across TCGA cell cohorts, ARFGEF2 mutation is significantly associated with the RNA expression of many other genes, with 519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARFGEF2-associated genes across cancer lineages are USP29, SRMS, and TEX46. Each is linked with ARFGEF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARFGEF2-to-partner and partner-to-ARFGEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by ARFGEF2-low versus ARFGEF2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF2→partner) and Y-score (partner→ARFGEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	USP29 →	+0.025	+4.087	<.001	.009	3	3
LARGE_INTESTINE	SRMS →	+0.747	+3.502	.008	.001	3	2
LARGE_INTESTINE	TEX46 →	+0.150	+2.912	<.001	.001	3	2
BLOOD_Leukemia	OR10K1 →	+0.402	+3.234	.001	.008	3	2
BLOOD_Leukemia	DPRX →	+0.110	+3.475	<.001	.006	3	2
BLOOD_Leukemia	LRRC3C →	+0.103	+3.796	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 519 associations by consensus.

USP29 by ARFGEF2 expression — URINARY_TRACT

Explore this box plot interactively →