ARFGAP3

Across TCGA pan-cancer cohorts, ARFGAP3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ARFGAP3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ARFGAP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARFGAP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where ARFGAP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.966	0.751	<.001	36	view →
LSCC	DFS	Quartile	II,III,IV	0.557	0.966	<.001	18	view →
CCRCC	DFS	Quartile	III,IV	0.443	0.778	.015	9	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	DFS	Quartile	All	0.164	0.337	.022	5	view →
HNSC	DFS	Median	III,IV	0.935	1.000	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ARFGAP3–UCEC (DFS)

Open the UCEC breakdown →