ARFGAP3

Across TCGA patient cohorts, ARFGAP3 mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGAP3-associated genes across cancer lineages are PEBP1P1, OR5F2P, and KRTAP20-3. Each is linked with ARFGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGAP3-to-partner and partner-to-ARFGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEBP1P1 grouped by ARFGAP3-low versus ARFGAP3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGAP3→partner) and Y-score (partner→ARFGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PEBP1P1 →	+0.123	+4.642	<.001	.004	3	2
UCEC	OR5F2P →	+0.131	+2.550	.001	.006	3	2
UCEC	KRTAP20-3 →	+0.112	+4.890	<.001	.002	3	2
UCEC	VN1R96P →	+0.107	+3.088	.001	.001	3	2
BLCA	RNU4-28P →	+0.210	+4.788	<.001	.006	3	2
SKCM	MTND2P32 →	+0.061	+2.819	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

PEBP1P1 by ARFGAP3 expression — BLCA

Explore this box plot interactively →