ARFGAP3

Across TCGA patient cohorts, ARFGAP3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGAP3-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Annexin-1. Each is linked with ARFGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGAP3-to-partner and partner-to-ARFGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ARFGAP3-low versus ARFGAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGAP3→partner) and Y-score (partner→ARFGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.375	-3.000	.009	.037	3	1
UCEC	ERK2 →	+0.219	+3.000	.049	.037	3	1
UCEC	Annexin-1 →	+0.904	+3.000	.002	.037	1	1
UCEC	Shc_pY317 →	-0.302	-3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

EGFR_pY1068 by ARFGAP3 expression — UCEC

Explore this box plot interactively →