ARFGAP2

Across TCGA cell cohorts, ARFGAP2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ARFGAP2-associated genes across cancer lineages are CCKAR, OR52K1, and H2BW2. Each is linked with ARFGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGAP2-to-partner and partner-to-ARFGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCKAR grouped by ARFGAP2-low versus ARFGAP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGAP2→partner) and Y-score (partner→ARFGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCKAR →	+0.032	+4.824	<.001	<.001	3	2
LARGE_INTESTINE	OR52K1 →	+0.012	+3.632	<.001	.003	3	1
SKIN	H2BW2 →	+0.084	+4.467	<.001	.004	3	1
SKIN	CUX2 →	+0.039	+4.095	<.001	.009	3	1
SKIN	OR11H1 →	+0.025	+4.467	.006	.004	3	1
SKIN	SLC22A7 →	+0.027	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CCKAR by ARFGAP2 expression — BLOOD_Leukemia

Explore this box plot interactively →