ARFGAP1

Across TCGA patient cohorts, ARFGAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGAP1-associated genes across cancer lineages are RN7SKP260, RNA5SP339, and ROPN1L-AS1. Each is linked with ARFGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGAP1-to-partner and partner-to-ARFGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP260 grouped by ARFGAP1-low versus ARFGAP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGAP1→partner) and Y-score (partner→ARFGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SKP260 →	+0.438	+6.102	<.001	.001	3	2
LIHC	RNA5SP339 →	+0.300	+6.008	<.001	.002	3	2
COAD	ROPN1L-AS1 →	+0.473	+4.870	<.001	.002	3	2
UCEC	RPL23AP4 →	+0.075	+2.215	<.001	.003	3	2
BLCA	RNU6-416P →	+0.329	+4.588	<.001	.008	3	2
LIHC	MIR7976 →	+0.482	+5.268	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,728 associations by consensus.

RN7SKP260 by ARFGAP1 expression — LUSC

Explore this box plot interactively →