ARFGAP1

Across TCGA cell cohorts, ARFGAP1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ARFGAP1-associated genes across cancer lineages are LRRTM3, DRD3, and GP9. Each is linked with ARFGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGAP1-to-partner and partner-to-ARFGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRTM3 grouped by ARFGAP1-low versus ARFGAP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGAP1→partner) and Y-score (partner→ARFGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRTM3 →	+0.006	+5.539	<.001	.003	3	2
LARGE_INTESTINE	DRD3 →	+0.008	+3.240	<.001	.004	3	1
LARGE_INTESTINE	GP9 →	+0.067	+2.933	.002	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	CRX →	+0.018	+3.722	.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	TPSG1 →	+0.048	+4.129	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

LRRTM3 by ARFGAP1 expression — BLOOD_Leukemia

Explore this box plot interactively →